Two ICU morning meetings (Academic Year 2007-2008) will be devoted a Journal Club on both dates below.
Anesthesia meetings will continue as normal in the afternoon.

22.05.08 0700   Journal Club - PROWESS Study Group   Prof. Perel / Dr. Segal / Dr. Nini

29.05.08 0700   Journal Club - ADDRESS Study Group   Prof. Perel / Dr. Segal / Dr. Nini

All residents are asked to prepare for presentation either the ADDRESS (+ followup) or PROWESS study group from the list below.
Please review the other articles for active participation in the discussion.

Please inform Dr. Nini which presentation you have chosen to prepare

The articles concerned may be download here in pdf format:

References
Article - Author - Publication Journal - Date	Size - Format	Download
EFFICACY AND SAFETY OF RECOMBINANT HUMAN ACTIVATED PROTEIN C FOR SEVERE SEPSIS  PROWESS STUDY GROUP GORDON R. BERNARD, M.D., JEAN-LOUIS VINCENT, M.D., PH.D., PIERRE-FRANCOIS LATERRE et al. N Engl J Med, Vol. 344, No. 10 Published at www.nejm.org on March 8, 2001	545 KB Adobe***
Drotrecogin Alfa (Activated) for Adults with Severe Sepsis and a Low Risk of Death  ADDRESS PAPER Edward Abraham, M.D., Pierre-Fran?ois Laterre, M.D., Rekha Garg, M.D.,et al. N Engl J Med 2005;353:1332-41 Published at www.nejm.org on Sep 29, 2005	140 KB Adobe***
ADDRESS (ADministration of DRotrecogin alfa [activated] in Early stage Severe Sepsis) long-term follow-up: One-year safety and efficacy evaluation   ADDRESS FOLLOWUP Pierre-Francois Laterre, MD; Edward Abraham, MD; Jonathan M. Janes, FRCP; Benjamin L. Trzaskoma, MS; Nancy L. Correll; Frank V. Booth, MD Crit Care Med 2007 Vol. 35, No. 6 Published at www.nejm.org (2007)	853 KB Adobe***
Recombinant human activated protein C sentenced to the death of a thousand cuts?   EDITORIAL James M. O’Brien, MD, MSc, Division of Pulmonary, Allergy, Critical Care and Sleep The Ohio State University Medical Center Columbus, OH Crit Care Med 2007 Vol. 35, No. 6 Published at www.nejm.org (2007)	84 KB Adobe***
FDA BRIEFING DOCUMENT: ANTI-INFECTIVE ADVISORY COMMITTEE DROTRECOGIN ALFA (ACTIVATED) [RECOMBINANT HUMAN ACTIVATED PROTEIN C (rhAPC)] XIGRIS™    SEPTEMBER 12, 2001	488 KB Adobe***

*** "Please note: In order not to infringe copyright protection, licensed copies of pdf files have been downloaded from the hospital library via the Shebanet Portal"

Further details from Dr. Asaph Nini

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